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Clinical study evaluating efficacy of PD-1 blockade in resected early-stage mismatch repair deficient (MMRd) tumors with ctDNA-detected MRD

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Trial Profile

Clinical study evaluating efficacy of PD-1 blockade in resected early-stage mismatch repair deficient (MMRd) tumors with ctDNA-detected MRD

Status: Completed
Phase of Trial: Phase IV

Latest Information Update: 23 Jun 2025

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At a glance

  • Drugs Pembrolizumab (Primary)
  • Indications Solid tumours
  • Focus Therapeutic Use

Most Recent Events

  • 23 Jun 2025 New trial record
  • 30 Apr 2025 Primary end-point (ctDNA clearance at 6 months in 40% of study patients) met, 85% (11/13) of patients in Arm A (Interventional) achieved ctDNA clearance at 6 months.
  • 30 Apr 2025 Results presented at the 116th Annual Meeting of the American Association for Cancer Research.

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