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First In Human, Multi-Center Open-Label Randomized Trial to Assess Safety of Rincell-1 Otic Neural Progenitor Cell-Based Therapy and Standard Care vs Standard Care Alone, in Adults With Neural Hearing Loss Eligible for Cochlear Implantation

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Trial Profile

First In Human, Multi-Center Open-Label Randomized Trial to Assess Safety of Rincell-1 Otic Neural Progenitor Cell-Based Therapy and Standard Care vs Standard Care Alone, in Adults With Neural Hearing Loss Eligible for Cochlear Implantation

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 12 Oct 2026

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At a glance

  • Drugs Cell replacements (Primary)
  • Indications Hearing loss; Presbycusis; Sensorineural hearing loss
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Rinri Therapeutics

Most Recent Events

  • 01 Oct 2026 Planned End Date changed from 1 Oct 2028 to 1 Aug 2029.
  • 01 Oct 2026 Planned primary completion date changed from 1 Jul 2028 to 1 May 2029.
  • 01 Oct 2026 Planned initiation date changed from 1 Nov 2026 to 1 Sep 2027.

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