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An Exploratory Phase 1b, Multicenter, Randomized, Open-Label Study to Investigate the Impact of the Administration of Intravenous VH3810109 With or Without Oral Fostemsavir in Combination With Integrase Inhibitor-Based Antiretroviral Therapy on the Viral Reservoir in Adults Living With HIV-1

Trial Profile

An Exploratory Phase 1b, Multicenter, Randomized, Open-Label Study to Investigate the Impact of the Administration of Intravenous VH3810109 With or Without Oral Fostemsavir in Combination With Integrase Inhibitor-Based Antiretroviral Therapy on the Viral Reservoir in Adults Living With HIV-1

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 19 Jan 2026

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At a glance

  • Drugs GSK 3810109 (Primary) ; Fostemsavir
  • Indications HIV-1 infections
  • Focus Therapeutic Use
  • Acronyms ENTRANCE
  • Sponsors ViiV Healthcare

Most Recent Events

  • 26 Dec 2025 Planned primary completion date changed from 24 Feb 2027 to 18 Jan 2027.
  • 07 Aug 2025 Status changed from not yet recruiting to recruiting.
  • 17 Jul 2025 New trial record

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