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A Phase 2a, Randomized, Double-blind, Placebo-controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1920 in Adult Participants With PMN (Primary Membranous Nephropathy) Who Are at a High Risk for Disease Progression

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Trial Profile

A Phase 2a, Randomized, Double-blind, Placebo-controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1920 in Adult Participants With PMN (Primary Membranous Nephropathy) Who Are at a High Risk for Disease Progression

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 14 Dec 2025

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At a glance

  • Drugs ALXN 1920 (Primary) ; Rituximab
  • Indications Membranous glomerulonephritis
  • Focus Therapeutic Use
  • Acronyms AUTUMN
  • Sponsors Alexion AstraZeneca Rare Disease

Most Recent Events

  • 06 Oct 2025 Planned End Date changed from 12 Mar 2027 to 12 Feb 2027.
  • 06 Oct 2025 Planned primary completion date changed from 12 Mar 2027 to 12 Feb 2027.
  • 24 Sep 2025 Status changed from not yet recruiting to recruiting.

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