Trial Profile

A Modular Phase I/II, Open-label, Multi-Centre Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 16 Sep 2025

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At a glance

Drugs AZD 3632 (Primary) ; Antineoplastics; Posaconazole
Indications Acute myeloid leukaemia; Haematological malignancies; Myelodysplastic syndromes
Focus Adverse reactions; First in man
Acronyms MOMENTUM
Sponsors AstraZeneca

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