Trial Profile

A Randomized, Double-Blind, Placebo-Controlled, First-In-Human Study of the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ALN-CFB, an Investigational siRNA Therapeutic Against Complement Factor B, in Participants With Paroxysmal Nocturnal Hemoglobinuria and Persistent Anemia on Approved C5-Inhibitor Therapy

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 11 Jul 2026

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At a glance

14 Jan 2026 Planned End Date changed from 4 Jan 2030 to 15 Jul 2031.
14 Jan 2026 Planned primary completion date changed from 11 Oct 2029 to 29 Nov 2029.
14 Jan 2026 Planned initiation date changed from 28 Nov 2025 to 16 Jan 2026.

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