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A Phase 1a, Open-label, Multicenter, Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of KQB548 in Participants With Advanced Solid Malignancies With a KRAS G12D Mutation

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Trial Profile

A Phase 1a, Open-label, Multicenter, Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of KQB548 in Participants With Advanced Solid Malignancies With a KRAS G12D Mutation

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 28 Nov 2025

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At a glance

  • Drugs KQB 548 (Primary) ; Antineoplastics
  • Indications Adenocarcinoma; Colorectal cancer; Non-small cell lung cancer; Pancreatic ductal carcinoma; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Kumquat Biosciences

Most Recent Events

  • 09 Oct 2025 New trial record
  • 08 Oct 2025 According to Bayer media release, the company announced today the initiation of a Phase I clinical trial.
  • 12 Aug 2025 According to Bayer media release, Kumquat received U.S. Food and Drug Administration (FDA) clearance of the investigational new drug (IND) for its KRAS G12D inhibitor in July 2025.

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