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A Phase Ia/Ib Dose-Escalation and Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Patients With Locally Advanced Or Metastatic ER-Positive, HER2-Negative Breast Cancer Who Have Previously Progressed During or After CDK4/6 Inhibitor Therapy

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Trial Profile

A Phase Ia/Ib Dose-Escalation and Expansion Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Patients With Locally Advanced Or Metastatic ER-Positive, HER2-Negative Breast Cancer Who Have Previously Progressed During or After CDK4/6 Inhibitor Therapy

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 21 Nov 2025

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At a glance

  • Drugs GDC 0587 (Primary) ; Giredestrant (Primary) ; Omeprazole (Primary)
  • Indications Early breast cancer; HER2 negative breast cancer
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors Genentech

Most Recent Events

  • 17 Nov 2025 Planned initiation date changed from 1 Nov to 15 Dec.
  • 14 Oct 2025 New trial record

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