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Peds IMPACT: Phase I Study -To Assess Safety and Feasibility of IL-8 Receptor Modified Patient-derived Activated CD70 CAR T Cell Therapy in Newly Diagnosed and Recurrent CD70+ Pediatric High-Grade Gliomas (pHGG) and Diffuse Intrinsic Pontine Glioma (ndDIPG)

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Trial Profile

Peds IMPACT: Phase I Study -To Assess Safety and Feasibility of IL-8 Receptor Modified Patient-derived Activated CD70 CAR T Cell Therapy in Newly Diagnosed and Recurrent CD70+ Pediatric High-Grade Gliomas (pHGG) and Diffuse Intrinsic Pontine Glioma (ndDIPG)

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 03 Jul 2026

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At a glance

  • Drugs IMGK 01 (Primary)
  • Indications Glioma
  • Focus Adverse reactions; First in man
  • Acronyms Peds IMPACT

Most Recent Events

  • 22 May 2026 Status changed from recruiting to not yet recruiting.
  • 22 May 2026 Planned number of patients changed from 18 to 24.
  • 31 Oct 2025 New trial record

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