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A Randomized Clinical Trial Evaluating Single Versus Multiple Intraocular Injections of ADX-2191 in Patients With Primary Vitreoretinal Lymphoma

Trial Profile

A Randomized Clinical Trial Evaluating Single Versus Multiple Intraocular Injections of ADX-2191 in Patients With Primary Vitreoretinal Lymphoma

Status: Planning
Phase of Trial: Phase II

Latest Information Update: 05 Nov 2025

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At a glance

  • Drugs Methotrexate (Primary)
  • Indications Intraocular lymphoma
  • Focus Therapeutic Use

Most Recent Events

  • 05 Nov 2025 New trial record
  • 28 Aug 2025 According to an Aldeyra Therapeutics media release, proposed clinical trial, which received Special Protocol Assessment agreement from the U.S. Food and Drug Administration, is designed to compare cancer cell clearance after 30 days of therapy in up to 20 patients following 1:1 randomization to receive either a single intraocular injection or eight intraocular injections of ADX-2191. The clinical trial is expected to begin in the second half of 2025 and conclude in 2026.

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