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A Phase 1 target-engagement study in MDD patients on an SSRI, evaluating the effects of EVX-301 on levels of serotonin and its main metabolite (5-HIAA) in the cerebrospinal fluid (CSF)

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Trial Profile

A Phase 1 target-engagement study in MDD patients on an SSRI, evaluating the effects of EVX-301 on levels of serotonin and its main metabolite (5-HIAA) in the cerebrospinal fluid (CSF)

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 24 Feb 2026

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At a glance

  • Drugs Oxitriptan (Primary)
  • Indications Major depressive disorder
  • Focus Adverse reactions

Most Recent Events

  • 09 Feb 2026 According to the Evecxia Media Release, status changed from planning to recruiting.
  • 09 Feb 2026 According to the Evecxia Media Release, first patient has been dosed in this Phase 1b randomized, placebo-controlled target-engagement study. Topline results are anticipated in Q2 2026.
  • 06 Nov 2025 New trial record

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