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Phase 1, 2-Cohort, Open-label, Fixed-sequence, Drug-drug Interaction Study to Evaluate the Effect of Repotrectinib on the Pharmacokinetics of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

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Trial Profile

Phase 1, 2-Cohort, Open-label, Fixed-sequence, Drug-drug Interaction Study to Evaluate the Effect of Repotrectinib on the Pharmacokinetics of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 29 Jan 2026

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At a glance

  • Drugs Repotrectinib (Primary) ; Bupropion; Digoxin; Flurbiprofen; Metformin; Omeprazole; Rosuvastatin
  • Indications Adenocarcinoma; CNS cancer; Lymphoma; Multiple myeloma; Non-small cell lung cancer; Solid tumours
  • Focus Pharmacokinetics
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 26 Jan 2026 Status changed from not yet recruiting to recruiting.
  • 06 Nov 2025 New trial record

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