Trial Profile

A Randomized, Double-Blind, Placebo-Controlled Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy and in Combination With Tirzepatide in Adults With Overweight and Obesity

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 05 Jan 2026

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At a glance

15 Dec 2025 According to a Rona Therapeutics media release, company announced successful completion of Cohort 1 dosing in phase 1 first-in-human clinical study of RN3161, for the treatment of obesity. Cohort 1 demonstrated a favorable initial safety and tolerability profile, representing the first clinical milestone for Rona's INHBE program. Additional cohorts are expected to be completed in 2026.
24 Nov 2025 Status changed from not yet recruiting to recruiting.
10 Nov 2025 New trial record

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