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Phase II Study of Dose-Adjusted EPOCH ± Rituximab + Ponatinib for Adults With Newly-Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia/Lymphoma

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Trial Profile

Phase II Study of Dose-Adjusted EPOCH ± Rituximab + Ponatinib for Adults With Newly-Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia/Lymphoma

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 23 Feb 2026

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At a glance

  • Drugs Ponatinib (Primary) ; Cyclophosphamide; Doxorubicin; Etoposide; Filgrastim; Pegfilgrastim; Prednisone; Rituximab; Vincristine
  • Indications Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Therapeutic Use

Most Recent Events

  • 20 Feb 2026 Planned initiation date (estimated date of first patient enrollment) changed from 1 May 2026 to 15 Mar 2026.
  • 20 Feb 2026 Status changed from not yet recruiting to recruiting.
  • 10 Nov 2025 New trial record

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