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A Phase 1b, Open-label, Multi-center, Randomized Study Evaluating the Safety and Tolerability of AZD0120, an Autologous CD19/BCMA Targeting Chimeric Antigen Receptor T-cells, in Adults With Refractory Relapsing or Progressive Multiple Sclerosis

Trial Profile

A Phase 1b, Open-label, Multi-center, Randomized Study Evaluating the Safety and Tolerability of AZD0120, an Autologous CD19/BCMA Targeting Chimeric Antigen Receptor T-cells, in Adults With Refractory Relapsing or Progressive Multiple Sclerosis

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Feb 2026

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At a glance

  • Drugs AZD 0120 (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions
  • Acronyms ZENITH
  • Sponsors AstraZeneca

Most Recent Events

  • 02 Feb 2026 Planned End Date changed from 8 Dec 2028 to 7 Dec 2028.
  • 02 Feb 2026 Planned primary completion date changed from 8 Dec 2028 to 7 Dec 2028.
  • 30 Dec 2025 Planned number of patients changed from 18 to 24.

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