Trial Profile

Phase 1/2 Master Protocol for Open-Label, Multi-Centre, Single-Arm Sub-Studies, First in Human Clinical Studies of TCR-T Therapy (Autologous TCR- Modified T-Cell Therapy) Targeting Mutated Kirsten Rat Sarcoma (mutKRAS) Administered in Metastatic or Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC) Adult Patients With Specific mutKRAS and Human Leukocyte Antigen (HLA) Genotypes

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 12 Nov 2025

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At a glance

Drugs ANOC 001 (Primary) ; ANOC 002 (Primary) ; ANOC 003 (Primary) ; Cyclophosphamide; Fludarabine
Indications Adenocarcinoma; Pancreatic ductal carcinoma
Focus Adverse reactions; First in man; Therapeutic Use
Sponsors Anocca

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