Trial Profile

A Phase 1, Single-Sequence, Two-Period Crossover, Open-Label Study to Determine the Potential Induction Effect of Multiple 100 mg BID Oral Doses of Nirogacestat on a Cocktail of CYP Probe Substrates CYP2B6 (Bupropion), CYP2C8 (Repaglinide), CYP2C9 (Flurbiprofen), CYP2C19 (Omeprazole), and CYP3A4 (Midazolam) in Healthy Males

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 16 Dec 2025

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At a glance

Drugs Nirogacestat (Primary) ; Bupropion; Flurbiprofen; Midazolam; Omeprazole; Repaglinide
Indications Fibroma; Multiple myeloma; Ovarian cancer
Focus Pharmacokinetics
Sponsors SpringWorks Therapeutics

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