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A Phase 1, First-in-Human Study of MEN2501, a KIF18A Inhibitor, as Monotherapy in Participants With Platinum-Resistant Ovarian Cancer

Trial Profile

A Phase 1, First-in-Human Study of MEN2501, a KIF18A Inhibitor, as Monotherapy in Participants With Platinum-Resistant Ovarian Cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Feb 2026

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At a glance

  • Drugs MEN 2501 (Primary)
  • Indications Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Focus Adverse reactions; First in man
  • Sponsors Stemline Therapeutics

Most Recent Events

  • 03 Feb 2026 According to InSilico Medicine media release, following IND approval for this program, Insilico received the first development and regulatory milestone payment of USD 3 million in July 2025.
  • 03 Feb 2026 According to InSilico Medicine media release, company announced that it has received USD 5 million from Menarini Group (Menarini) as an additional milestone payment, following the completion of first-in-patient dosing in a Phase 1 study of MEN2501, which was licensed to Menarini in January 2025.
  • 13 Nov 2025 New trial record

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