Trial Profile

A Phase 1/2, Open-Label, Multi-Center, Dose Escalation, Dose Expansion, and Single Repeat Dose Study of TSRA-196 in Adults With the PiZZ Genotype Who Have Lung and/or Liver Disease Associated With Severe Alpha-1 Antitrypsin Deficiency

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 17 Nov 2025

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At a glance

Drugs TSRA 196 (Primary)
Indications Alpha 1-antitrypsin deficiency; Bronchiectasis; Emphysema; Hepatic fibrosis
Focus Adverse reactions; Therapeutic Use
Sponsors Tessera Therapeutics

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