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A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer

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Trial Profile

A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 23 Jan 2026

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At a glance

  • Drugs Ivonescimab (Primary) ; Bevacizumab; FOLFOX regimen
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms HARMONi-GI3
  • Sponsors Summit Therapeutics

Most Recent Events

  • 15 Jan 2026 Last checked against ClinicalTrials.gov: US National Institutes of Health
  • 18 Nov 2025 New trial record
  • 13 Nov 2025 Status changed from planning to recruiting.

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