Trial Profile

A phase 3 trial evaluating first-line SC amivantamab with pembrolizumab and carboplatin versus 5-fluorouracil (5FU) plus pembrolizumab and platinum-based chemotherapy (cisplatin or carboplatin) in patients with HPV-unrelated R/M HNSCC

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 19 Nov 2025

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At a glance

Drugs Amivantamab (Primary) ; Carboplatin; Cisplatin; Fluorouracil; Pembrolizumab
Indications Head and neck cancer; Squamous cell cancer
Focus Therapeutic Use
Acronyms OrigAMI-5

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