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A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HMPL-A251 in Participants With Advanced or Metastatic HER2-Expressing Solid Tumors

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Trial Profile

A Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HMPL-A251 in Participants With Advanced or Metastatic HER2-Expressing Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 31 Dec 2025

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At a glance

  • Drugs HMPL-A251 (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Sponsors HUTCHMED

Most Recent Events

  • 17 Dec 2025 According to HUTCHMED media release, first patient received the first dose on December 16, 2025, in China.
  • 17 Dec 2025 Status changed from not yet recruiting to recruiting.
  • 19 Nov 2025 New trial record

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