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A single-arm, multicenter, open-label, Phase I/II trial of Allo-QuadCAR01-T, an allogeneic CAR-T-cell therapy targeting CD19 and CD20, for the treatment of relapsed or refractory B-cell malignancies - AVC-203-01

Trial Profile

A single-arm, multicenter, open-label, Phase I/II trial of Allo-QuadCAR01-T, an allogeneic CAR-T-cell therapy targeting CD19 and CD20, for the treatment of relapsed or refractory B-cell malignancies - AVC-203-01

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 16 Dec 2025

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At a glance

  • Drugs AVC 203 (Primary)
  • Indications B-cell leukaemia; B-cell lymphoma; Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma
  • Focus Adverse reactions; First in man; Registrational; Therapeutic Use
  • Acronyms QUADvance
  • Sponsors AvenCell Therapeutics

Most Recent Events

  • 04 Dec 2025 According to Avencell media release,The phase Ia dose escalation study is expected to be followed by a phase Ib dose expansion study and a Phase II pivotal trial.
  • 04 Dec 2025 According to Avencell media release, the FDA and the European Medicines Agency (EMA) have cleared the companys IND and approved the Clinical Trial Application (CTA)for this trial.
  • 19 Nov 2025 New trial record

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