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A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Sponsor-Open Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-781 in Healthy Participants and a Single-Arm, Open-Label Evaluation in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis

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Trial Profile

A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Sponsor-Open Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-781 in Healthy Participants and a Single-Arm, Open-Label Evaluation in Participants With Non-Cirrhotic Primary Sclerosing Cholangitis

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Feb 2026

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At a glance

  • Drugs TAK 781 (Primary)
  • Indications Primary sclerosing cholangitis
  • Focus Adverse reactions
  • Sponsors Takeda

Most Recent Events

  • 30 Jan 2026 Planned End Date changed from 16 Dec 2027 to 6 Apr 2028.
  • 30 Jan 2026 Planned primary completion date changed from 16 Dec 2027 to 6 Apr 2028.
  • 30 Jan 2026 Status changed from not yet recruiting to recruiting.

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