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A Randomized Phase II Study Evaluating Upfront SRT to All Brain Metastases Followed by Ivonescimab Plus Chemotherapy Versus Upfront Ivonescimab Plus Chemotherapy in Patients With Asymptomatic Active Brain Metastases From NSCLC

Trial Profile

A Randomized Phase II Study Evaluating Upfront SRT to All Brain Metastases Followed by Ivonescimab Plus Chemotherapy Versus Upfront Ivonescimab Plus Chemotherapy in Patients With Asymptomatic Active Brain Metastases From NSCLC

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 14 Jun 2026

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At a glance

  • Drugs Ivonescimab (Primary) ; Pemetrexed (Primary) ; Antineoplastics
  • Indications Brain metastases; Non-small cell lung cancer
  • Focus Therapeutic Use

Most Recent Events

  • 04 Jun 2026 Planned End Date changed from 1 Oct 2031 to 1 Apr 2032.
  • 04 Jun 2026 Planned primary completion date changed from 1 Jan 2031 to 1 Jan 2032.
  • 04 Jun 2026 Planned initiation date changed from 1 Apr 2026 to 1 Nov 2026.

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