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A Phase I First-in-human Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD4063 in Adults With Phospholamban R14del Dilated Cardiomyopathy

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Trial Profile

A Phase I First-in-human Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD4063 in Adults With Phospholamban R14del Dilated Cardiomyopathy

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 09 Sep 2026

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At a glance

  • Drugs AZD 4063 (Primary)
  • Indications Dilated cardiomyopathy
  • Focus Adverse reactions; First in man
  • Acronyms PULSE
  • Sponsors AstraZeneca

Most Recent Events

  • 04 Sep 2026 The protocol has been amended to change in treatment arm size and modifications in primary endpoints.
  • 04 Sep 2026 Planned number of patients changed from 31 to 23.
  • 30 Dec 2025 Planned End Date changed from 17 Nov 2027 to 22 Nov 2027.

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