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A Phase I, 2-Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-ascending Doses of Intrathecally Administered RG6496 in a Randomized, Placebo-controlled, Investigator/Participant-blind Study With an Open-label Extension in Huntington's Disease Gene Expansion Carriers

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Trial Profile

A Phase I, 2-Part Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-ascending Doses of Intrathecally Administered RG6496 in a Randomized, Placebo-controlled, Investigator/Participant-blind Study With an Open-label Extension in Huntington's Disease Gene Expansion Carriers

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 02 Dec 2025

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At a glance

  • Drugs RG 6496 (Primary)
  • Indications Huntington's disease
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms POINT-HD
  • Sponsors Roche

Most Recent Events

  • 02 Dec 2025 New trial record

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