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A Phase 1, Open-Label, Multicenter Study to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy of MK-4716 as Monotherapy and as Part of Combination Therapy in Participants With KRAS-Altered Advanced or Metastatic Solid Tumors

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Trial Profile

A Phase 1, Open-Label, Multicenter Study to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy of MK-4716 as Monotherapy and as Part of Combination Therapy in Participants With KRAS-Altered Advanced or Metastatic Solid Tumors

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 05 Jan 2026

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At a glance

  • Drugs Cetuximab (Primary) ; MK 4716 (Primary) ; Pembrolizumab (Primary)
  • Indications Non-small cell lung cancer; Sarcoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Merck Sharp & Dohme

Most Recent Events

  • 30 Dec 2025 Status changed from not yet recruiting to recruiting.
  • 03 Dec 2025 New trial record

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