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A Two-Part, Single Ascending Dose and Positron Emission Tomography Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Receptor Occupancy After Single Oral Dose Administration of ENX-205 in Healthy Adult Participants

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Trial Profile

A Two-Part, Single Ascending Dose and Positron Emission Tomography Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Receptor Occupancy After Single Oral Dose Administration of ENX-205 in Healthy Adult Participants

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 01 Jun 2026

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At a glance

  • Drugs ENX-205 (Primary)
  • Indications Mood disorders; Post-traumatic stress disorders
  • Focus Adverse reactions
  • Sponsors Engrail Therapeutics

Most Recent Events

  • 28 May 2026 Status changed from recruiting to completed.
  • 27 Feb 2026 Planned number of patients changed from 40 to 60.
  • 27 Feb 2026 Planned End Date changed from 1 Mar 2026 to 1 Apr 2026.

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