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A Phase 1b/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

Trial Profile

A Phase 1b/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 12 Jan 2026

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At a glance

  • Drugs Bevacizumab (Primary) ; Enzalutamide (Primary) ; Fluorouracil (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; Risvutatug rezetecan (Primary)
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Prostate cancer; Rectal cancer
  • Focus Adverse reactions
  • Sponsors GlaxoSmithKline Research & Development

Most Recent Events

  • 07 Jan 2026 Planned number of patients changed from 72 to 84.
  • 11 Dec 2025 New trial record

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