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A Randomized, Open-label, Multicenter, Phase 3 Trial of Ivonescimab Alone or With Ligufalimab Versus Pembrolizumab in First-line Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

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Trial Profile

A Randomized, Open-label, Multicenter, Phase 3 Trial of Ivonescimab Alone or With Ligufalimab Versus Pembrolizumab in First-line Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Status: Not yet recruiting
Phase of Trial: Phase III

Latest Information Update: 15 Dec 2025

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At a glance

  • Drugs Ivonescimab (Primary) ; Ligufalimab (Primary) ; Pembrolizumab
  • Indications Head and neck cancer; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms ILLUMINE

Most Recent Events

  • 15 Dec 2025 New trial record

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