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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With an ANGPTL3 Antibody in Participants With Diabetic Kidney Disease

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Trial Profile

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With an ANGPTL3 Antibody in Participants With Diabetic Kidney Disease

Status: Not yet recruiting
Phase of Trial: Phase II

Latest Information Update: 15 Dec 2025

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At a glance

  • Drugs ALN ANG3 (Primary) ; Evinacumab
  • Indications Diabetic nephropathies
  • Focus Therapeutic Use
  • Acronyms ANCHOR-POC
  • Sponsors Regeneron Pharmaceuticals

Most Recent Events

  • 15 Dec 2025 New trial record

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