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A Phase 1, Open-Label Study to Assess the Enzyme Inducing Effects of Carbamazepine on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants

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Trial Profile

A Phase 1, Open-Label Study to Assess the Enzyme Inducing Effects of Carbamazepine on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Jan 2026

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At a glance

  • Drugs Carbamazepine (Primary) ; Mirdametinib (Primary)
  • Indications Aortic aneurysm; Glioma; Histiocytosis; Malignant melanoma; Nerve sheath neoplasms; Neurofibromatosis 1; Solid tumours; Vascular malformations
  • Focus Pharmacokinetics
  • Sponsors SpringWorks Therapeutics

Most Recent Events

  • 16 Dec 2025 New trial record

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