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A multi-center, open-label, drug-drug interaction study to evaluate the effect of pralsetinib (Gavreto) on the pharmacokinetics of CYP3A4, CYP2C8, and CYP2C9 substrates, and hormones estradiol/norethisterone acetate in patients with advanced or metastatic solid tumors. - RGL-RET-001

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Trial Profile

A multi-center, open-label, drug-drug interaction study to evaluate the effect of pralsetinib (Gavreto) on the pharmacokinetics of CYP3A4, CYP2C8, and CYP2C9 substrates, and hormones estradiol/norethisterone acetate in patients with advanced or metastatic solid tumors. - RGL-RET-001

Status: Not yet recruiting
Phase of Trial: Phase III/IV

Latest Information Update: 17 Dec 2025

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At a glance

  • Drugs Pralsetinib (Primary)
  • Indications Solid tumours
  • Focus Pharmacokinetics
  • Acronyms RGL-RET-001
  • Sponsors Rigel Pharmaceuticals

Most Recent Events

  • 17 Dec 2025 New trial record

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