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An ISA to Master Protocol ARGX-999-2-MG-2000 for an Exploratory, Phase 2a, Proof-of-Concept Study to Evaluate the Safety, Tolerability, and Efficacy of Empasiprubart IV as Add-On Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

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Trial Profile

An ISA to Master Protocol ARGX-999-2-MG-2000 for an Exploratory, Phase 2a, Proof-of-Concept Study to Evaluate the Safety, Tolerability, and Efficacy of Empasiprubart IV as Add-On Therapy to Efgartigimod IV in Participants With AChR-Ab Seropositive Generalized Myasthenia Gravis With a Partial Clinical Response to Efgartigimod

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 11 Feb 2026

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At a glance

  • Drugs Empasiprubart (Primary) ; Efgartigimod alfa
  • Indications Myasthenia gravis
  • Focus Adverse reactions; Proof of concept
  • Acronyms ADAPT Forward 1 - ISA1 - a
  • Sponsors argenx

Most Recent Events

  • 12 Jan 2026 Status changed from not yet recruiting to recruiting.
  • 22 Dec 2025 New trial record

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