Trial Profile

KEYMAKER-U01 Substudy 01F: A Phase 1b/2 Umbrella Study With Rolling Arms of Investigational Agents for Previously Treated Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 03 Mar 2026

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At a glance

Drugs Calderasib (Primary) ; Cetuximab; Patritumab Deruxtecan; Sacituzumab Tirumotecan
Indications Non-small cell lung cancer
Focus Adverse reactions; Therapeutic Use
Sponsors Merck Sharp & Dohme Corp.

27 Feb 2026 Planned End Date changed from 20 Jul 2036 to 6 May 2037.
27 Feb 2026 Planned initiation date changed from 23 Feb 2026 to 23 Mar 2026.
27 Feb 2026 Status changed from not yet recruiting to recruiting.

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