Trial Profile

A 40-week study comparing the efficacy, safety and patient-reported outcomes of once weekly IcoSema and once or twice daily insulin degludec/insulin aspart 100 units/mL, both treatment arms with or without oral anti-diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily pre-mixed insulin. COMBINE 5 - NN1535-8377

Status: Discontinued

Phase of Trial: Phase III

Latest Information Update: 29 Dec 2025

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At a glance

Drugs Insulin degludec/insulin aspart (Primary) ; Insulin-icodec/semaglutide (Primary)
Indications Type 2 diabetes mellitus
Focus Registrational; Therapeutic Use
Acronyms COMBINE 5
Sponsors Novo Nordisk

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