Trial Profile

MODeFIRe-1 (Molecular Degrader for Inhibitor Resistance): A Phase 2, Open-Label, Multicenter Study of Oral MRT-2359 in Combination With Apalutamide in Patients With Castration-Resistant Prostate Cancer

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 07 Aug 2026

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At a glance

04 Aug 2026 Status changed from planning to recruiting.
24 Feb 2026 Accoridng to a Monte Rosa Therapeutics media release, Company plans to initiate a new, signal-confirming Phase 2 study of MRT-2359 targeting AR mutant patients in Q3 2026
31 Dec 2025 New trial record

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