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A Phase 1, 2-Part, Multicenter, Open-Label, First-in-Human Study of the Anti-Ly6E Exatecan Antibody-Drug Conjugate M7437 in Participants With Advanced Solid Tumors

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Trial Profile

A Phase 1, 2-Part, Multicenter, Open-Label, First-in-Human Study of the Anti-Ly6E Exatecan Antibody-Drug Conjugate M7437 in Participants With Advanced Solid Tumors

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 24 Jan 2026

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At a glance

  • Drugs M 7437 (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Carcinoma; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Pancreatic ductal carcinoma; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Focus Adverse reactions; First in man
  • Sponsors Merck KGaA

Most Recent Events

  • 07 Jan 2026 New trial record

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