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A Phase 1b Study of Pasritamig (JNJ-78278343), a T-cell Redirecting Agent Targeting Human Kallikrein 2 (KLK2), in Combination With JNJ-86974680, an A2a Receptor (A2aR) Antagonist, for Prostate Cancer

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Trial Profile

A Phase 1b Study of Pasritamig (JNJ-78278343), a T-cell Redirecting Agent Targeting Human Kallikrein 2 (KLK2), in Combination With JNJ-86974680, an A2a Receptor (A2aR) Antagonist, for Prostate Cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 18 Feb 2026

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At a glance

  • Drugs JNJ 86974680 (Primary) ; Pasritamig (Primary)
  • Indications Adenocarcinoma; Carcinoid tumour; Neuroendocrine carcinoma; Prostate cancer; Small cell lung cancer
  • Focus Adverse reactions
  • Sponsors Janssen Research & Development

Most Recent Events

  • 13 Feb 2026 Planned End Date changed from 9 Feb 2027 to 30 Apr 2027.
  • 12 Jan 2026 New trial record

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