Trial Profile

A Phase 3, Randomized, Open-label, Multicenter Study to Compare the Efficacy and Safety of BMS-986353, CD19-targeted NEX-T CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis (Breakfree-SSc)

Status: Not yet recruiting

Phase of Trial: Phase III

Latest Information Update: 20 Jan 2026

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At a glance

Drugs Zolacaptagene autoleucel (Primary) ; Cyclophosphamide; Fludarabine; Nintedanib; Rituximab; Tocilizumab
Indications Systemic scleroderma
Focus Registrational; Therapeutic Use
Acronyms Breakfree-SSc
Sponsors Juno Therapeutics

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