Trial Profile

In Treatment-Naive Patients With Primary Central Nervous System Lymphoma (PCNSL): A Multicenter Two-Cohort Study of Methotrexate Combined With Rituximab, Sintilimab and Pirtobrutinib (Prospective Interventional Cohort) vs. Real-World Investigator-Selected Treatment (Observational Cohort)

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 27 Jan 2026

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At a glance

Drugs Methotrexate (Primary) ; Pirtobrutinib (Primary) ; Rituximab (Primary) ; Sintilimab (Primary) ; Cytarabine; Ibrutinib; Orelabrutinib; Temozolomide; Thiotepa; Zanubrutinib
Indications Diffuse large B cell lymphoma; Non-Hodgkin's lymphoma
Focus Therapeutic Use

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