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A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

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Trial Profile

A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

Status: Not yet recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Feb 2026

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At a glance

  • Drugs Eloralintide (Primary)
  • Indications Obesity; Osteoarthritis
  • Focus Registrational; Therapeutic Use
  • Acronyms ENLIGHTEN-4
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 29 Jan 2026 New trial record

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