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A Phase 3, Randomized, Double-blind, Active-control Study of Pelabresib (DAK539) and Ruxolitinib vs. Placebo and Ruxolitinib in Adult Patients With Myelofibrosis Who Are JAK Inhibitor Naive

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Trial Profile

A Phase 3, Randomized, Double-blind, Active-control Study of Pelabresib (DAK539) and Ruxolitinib vs. Placebo and Ruxolitinib in Adult Patients With Myelofibrosis Who Are JAK Inhibitor Naive

Status: Not yet recruiting
Phase of Trial: Phase III

Latest Information Update: 03 Feb 2026

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At a glance

  • Drugs Pelabresib (Primary) ; Ruxolitinib (Primary)
  • Indications Myelofibrosis
  • Focus Registrational; Therapeutic Use
  • Acronyms MANIFEST-3
  • Sponsors Novartis Pharmaceuticals

Most Recent Events

  • 03 Feb 2026 New trial record

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