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Patient-Centered Study of Trastuzumab Deruxtecan (T-DXd) in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management Reflecting Real-World Clinical Practice

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Trial Profile

Patient-Centered Study of Trastuzumab Deruxtecan (T-DXd) in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management Reflecting Real-World Clinical Practice

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 03 Mar 2026

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At a glance

  • Drugs Pertuzumab (Primary) ; Trastuzumab-deruxtecan (Primary)
  • Indications HER2 positive breast cancer; Male breast cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms TOP-REAL

Most Recent Events

  • 25 Feb 2026 Status changed from not yet recruiting to recruiting.
  • 05 Feb 2026 New trial record

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