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An Open-label, Dose-escalation Phase Ib/II Clinical Trial of Recombinant Oncolytic Herpes Simplex Virus Type II (OH2) Therapeutic Injection (Vero Cell) for Human Use (rHSV2hGM-CSF) in Combination With Recombinant Oncolytic Herpes Simplex Virus Type II (BS006) Therapeutic Injection (Vero Cell) for Human Use (oHSV2-PD-L1/CD3-BsAb) for Advanced Solid Tumors.

Trial Profile

An Open-label, Dose-escalation Phase Ib/II Clinical Trial of Recombinant Oncolytic Herpes Simplex Virus Type II (OH2) Therapeutic Injection (Vero Cell) for Human Use (rHSV2hGM-CSF) in Combination With Recombinant Oncolytic Herpes Simplex Virus Type II (BS006) Therapeutic Injection (Vero Cell) for Human Use (oHSV2-PD-L1/CD3-BsAb) for Advanced Solid Tumors.

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 09 Feb 2026

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At a glance

  • Drugs BS-006 (Primary) ; OH 2 (Primary)
  • Indications Biliary cancer; Carcinoma; Gastric cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Oesophageal cancer; Pancreatic cancer; Soft tissue sarcoma; Solid tumours
  • Focus Adverse reactions
  • Sponsors Binhui Biopharmaceutical

Most Recent Events

  • 06 Feb 2026 New trial record

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