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A Phase 1 Clinical Trial to Evaluate the Safety, Pharmacokinetics, and in Vitro Neutralization of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS Administered in Multiple Doses and Routes to Adult Participants Without HIV-1

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Trial Profile

A Phase 1 Clinical Trial to Evaluate the Safety, Pharmacokinetics, and in Vitro Neutralization of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS Administered in Multiple Doses and Routes to Adult Participants Without HIV-1

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Apr 2026

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At a glance

  • Drugs PGT 121 (Primary) ; PGT 121 (Primary) ; TMB-380 (Primary) ; TMB-380 (Primary)
  • Indications HIV infections
  • Focus Adverse reactions; Pharmacodynamics; Pharmacokinetics

Most Recent Events

  • 07 Apr 2026 Status changed from not yet recruiting to recruiting.
  • 20 Feb 2026 Planned initiation date changed from 12 Jan 2026 to 6 Mar 2026.
  • 10 Feb 2026 New trial record

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