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A Phase 1, Open-label, Dose-Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of D3S-003 Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation

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Trial Profile

A Phase 1, Open-label, Dose-Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of D3S-003 Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 17 Apr 2026

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At a glance

  • Drugs D3S 003 (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors D3 Bio

Most Recent Events

  • 13 Apr 2026 Status changed from not yet recruiting to recruiting.
  • 06 Mar 2026 Status changed from planning to not yet recruiting.
  • 16 Feb 2026 New trial record

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