Trial Profile

A Phase 1, Open-label, Dose-escalation Study (ELEVATE-1) to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of a CD19/CD20 T-cell Engager in Participants With B-cell Driven Autoimmune Rheumatic Diseases (ARD)

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 20 Mar 2026

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At a glance

Drugs CMG 1A46 (Primary)
Indications Myositis; Rheumatoid arthritis; Sjogren's syndrome; Systemic lupus erythematosus
Focus Adverse reactions
Acronyms ELEVATE-1
Sponsors GSK

17 Mar 2026 Planned End Date changed from 24 Feb 2028 to 15 Mar 2028.
17 Mar 2026 Planned primary completion date changed from 24 Feb 2028 to 15 Mar 2028.
17 Mar 2026 Status changed from not yet recruiting to recruiting.

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