Trial Profile

A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in First-Line Claudin18.2-Positive, HER2-Negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 02 Mar 2026

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At a glance

Drugs Capecitabine (Primary) ; Nivolumab (Primary) ; Rilvegostomig (Primary) ; Sonesitatug-Vedotin (Primary) ; Zolbetuximab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
Focus Registrational; Therapeutic Use
Acronyms CLARITY-Gastric 02
Sponsors AstraZeneca

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